Calls for proposals

Paediatric Clinical Research Infrastructure Service Model (PRISM) is a European consortium aiming to strengthen the conduct of multinational paediatric research by providing infrastructure and expertise to investigator-initiated studies.

Funded by Horizon-Europe (GA101292607), PRISM selects, according to a two-stage procedure, pilot paediatric clinical studies to provide comprehensive, end-to-end support for multinational investigator-initiated studies conducted in 3 to 6 countries in Europe and Canada.

Short-listed projects get dedicated support from the PRISM consortium during the design and planning of the full application.

Following final assessment, selected projects receive funding covering the cost of investigation and trial coordination, and multinational trial management services provided by the PRISM consortium.

Key details

• Eligible studies: pragmatic, investigator-initiated randomised controlled trials comparing or optimising healthcare strategies (therapeutic, diagnostic or preventive interventions), and prospective observational cohort studies.
• Study population: birth to 18 years old. Any paediatric disease area except oncology and rare diseases.
• Recruitment: in 3 to 6 countries across Europe (EU, Norway, Switzerland, United Kingdom) and Canada, with a maximum of 15 sites (except cluster randomised controlled trials).
• Maximum study duration: 30 months, from study start-up to the close-out visit.
• Requested budget: 1–2 M€ for interventional studies, or up to 1 M€ for observational studies, including the mandatory ECRIN Coordinated Service Package.
• A single, non-commercial, experienced sponsor, with a sponsor representative where required.

Please read the call text and application guidelines in full before applying.

Questions: PRISM Joint Call Secretariat – call2026@prismeu.org

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